diff --git a/compiler/src/dotty/tools/dotc/core/Annotations.scala b/compiler/src/dotty/tools/dotc/core/Annotations.scala
index d6a99b12e3b3..608ae470cfa9 100644
--- a/compiler/src/dotty/tools/dotc/core/Annotations.scala
+++ b/compiler/src/dotty/tools/dotc/core/Annotations.scala
@@ -177,8 +177,14 @@ object Annotations {
       assert(myTree != null)
       myTree match {
         case treeFn: (Context ?=> Tree) @unchecked =>
+          val retainedFn = treeFn // for some reason treeFn is null if exception is thrown
+          var result: Tree | Null = null
           myTree = null
-          myTree = atPhaseBeforeTransforms(treeFn)
+          try
+            result = atPhaseBeforeTransforms(treeFn)
+            myTree = result
+          finally if result == null then
+            myTree = retainedFn // reset, if unit is suspended then it will re-enter this annotation
         case _ =>
       }
       myTree.asInstanceOf[Tree]
diff --git a/compiler/src/dotty/tools/dotc/core/tasty/TreeUnpickler.scala b/compiler/src/dotty/tools/dotc/core/tasty/TreeUnpickler.scala
index c6a334a33473..74e5ef08b874 100644
--- a/compiler/src/dotty/tools/dotc/core/tasty/TreeUnpickler.scala
+++ b/compiler/src/dotty/tools/dotc/core/tasty/TreeUnpickler.scala
@@ -170,11 +170,13 @@ class TreeUnpickler(reader: TastyReader,
             case ex: Exception => fail(ex)
   }
 
-  class TreeReader(val reader: TastyReader) {
+  class TreeReader(val reader: TastyReader, inInlineBody: Boolean = false) {
     import reader.*
 
-    def forkAt(start: Addr): TreeReader = new TreeReader(subReader(start, endAddr))
-    def fork: TreeReader = forkAt(currentAddr)
+    def forkAt(start: Addr, inInlineBody: Boolean = false): TreeReader =
+      new TreeReader(subReader(start, endAddr), inInlineBody)
+
+    def fork: TreeReader = forkAt(currentAddr, inInlineBody)
 
     def skipParentTree(tag: Int): Unit = {
       if tag == SPLITCLAUSE then ()
@@ -694,7 +696,7 @@ class TreeUnpickler(reader: TastyReader,
           val ctx1 = localContext(sym)(using ctx0).addMode(Mode.ReadPositions)
           inContext(sourceChangeContext(Addr(0))(using ctx1)) {
             // avoids space leaks by not capturing the current context
-            forkAt(rhsStart).readTree()
+            forkAt(rhsStart, inInlineBody = true).readTree()
           }
         })
       goto(start)
@@ -1580,21 +1582,14 @@ class TreeUnpickler(reader: TastyReader,
                   val d = ownerTpe.decl(name).atSignature(sig, target)
                   (if !d.exists then lookupInSuper else d).asSeenFrom(prefix)
 
-              val denot0 = inContext(ctx.addMode(Mode.ResolveFromTASTy)):
+              val denot = inContext(ctx.addMode(Mode.ResolveFromTASTy)):
                 searchDenot // able to resolve SourceInvisible members
 
-              val denot =
-                if
-                  denot0.symbol.exists
-                  && denot0.symbol.is(SourceInvisible)
-                  && denot0.symbol.isDefinedInSource
-                then
-                  searchDenot // fallback
-                else
-                  denot0
-
 
-              makeSelect(qual, name, denot)
+              val sel = makeSelect(qual, name, denot)
+              if denot == NoDenotation && inInlineBody && sel.denot.symbol.exists && sel.symbol.isDefinedInCurrentRun then
+                throw new ChangedMethodDenot(sel.denot.symbol)
+              sel
             case REPEATED =>
               val elemtpt = readTpt()
               SeqLiteral(until(end)(readTree()), elemtpt)
@@ -1901,6 +1896,9 @@ class TreeUnpickler(reader: TastyReader,
 
 object TreeUnpickler {
 
+  /** Specifically thrown when a SELECTin was written to TASTy, i.e. is expected to resolve, and then doesn't. */
+  private[dotc] final class ChangedMethodDenot(val resolved: Symbol) extends Exception
+
   /** Define the expected format of the tasty bytes
    *   - TopLevel: Tasty that contains a full class nested in its package
    *   - Term: Tasty that contains only a term tree
diff --git a/compiler/src/dotty/tools/dotc/inlines/Inlines.scala b/compiler/src/dotty/tools/dotc/inlines/Inlines.scala
index aeecd9c376e3..a09874ff56ee 100644
--- a/compiler/src/dotty/tools/dotc/inlines/Inlines.scala
+++ b/compiler/src/dotty/tools/dotc/inlines/Inlines.scala
@@ -19,6 +19,7 @@ import staging.StagingLevel
 import collection.mutable
 import reporting.{NotConstant, trace}
 import util.Spans.Span
+import dotty.tools.dotc.core.tasty.TreeUnpickler
 
 /** Support for querying inlineable methods and for inlining calls to such methods */
 object Inlines:
@@ -158,8 +159,18 @@ object Inlines:
       else if enclosingInlineds.length < ctx.settings.XmaxInlines.value && !reachedInlinedTreesLimit then
         val body =
           try bodyToInline(tree.symbol) // can typecheck the tree and thereby produce errors
-          catch case _: MissingInlineInfo =>
-            throw CyclicReference(ctx.owner)
+          catch
+            case _: MissingInlineInfo => throw CyclicReference(ctx.owner)
+            case err: TreeUnpickler.ChangedMethodDenot =>
+              // tested in sbt-test/tasty-compat/add-param-unroll2/a_v3/A.scala
+              if err.resolved.source == ctx.source then
+                report.error(em"""cannot inline ${tree.symbol}:
+                  |  The definition of ${err.resolved.showLocated}, defined in the current file, has changed incompatibly.
+                  |  Try inlining from a different file.""", tree.srcPos)
+                EmptyTree
+              else
+                // Tested in sbt-test/tasty-compat/add-param-unroll2/a_v3_2/C.scala
+                ctx.compilationUnit.suspend("suspending in case of possible generated methods")
         new InlineCall(tree).expand(body)
       else
         ctx.base.stopInlining = true