diff --git a/compiler/src/dotty/tools/dotc/typer/Applications.scala b/compiler/src/dotty/tools/dotc/typer/Applications.scala
index 17be2acc7378..de9caf05b550 100644
--- a/compiler/src/dotty/tools/dotc/typer/Applications.scala
+++ b/compiler/src/dotty/tools/dotc/typer/Applications.scala
@@ -2076,16 +2076,20 @@ trait Applications extends Compatibility {
   def resolveOverloaded(alts: List[TermRef], pt: Type)(using Context): List[TermRef] =
     record("resolveOverloaded")
 
-    /** Is `alt` a method or polytype whose result type after the first value parameter
+    /** Is `alt` a method or polytype whose approximated result type after the first value parameter
      *  section conforms to the expected type `resultType`? If `resultType`
      *  is a `IgnoredProto`, pick the underlying type instead.
+     *
+     *  Using approximated result types is necessary to avoid false negatives
+     *  due to incomplete type inference such as in tests/pos/i21410.scala.
      */
     def resultConforms(altSym: Symbol, altType: Type, resultType: Type)(using Context): Boolean =
       resultType.revealIgnored match {
         case resultType: ValueType =>
           altType.widen match {
-            case tp: PolyType => resultConforms(altSym, instantiateWithTypeVars(tp), resultType)
-            case tp: MethodType => constrainResult(altSym, tp.resultType, resultType)
+            case tp: PolyType => resultConforms(altSym, tp.resultType, resultType)
+            case tp: MethodType =>
+              constrainResult(altSym, wildApprox(tp.resultType), resultType)
             case _ => true
           }
         case _ => true
diff --git a/tests/pos/i21410.scala b/tests/pos/i21410.scala
new file mode 100644
index 000000000000..c3ba3ea862bc
--- /dev/null
+++ b/tests/pos/i21410.scala
@@ -0,0 +1,12 @@
+class A
+object Test:
+  type F[X] <: Any = X match
+    case A => Int
+
+  def foo[T](x: String): T = ???
+  def foo[U](x: U): F[U] = ???
+
+  val x1 = foo(A())
+  val y: Int = x1
+
+  val x2: Int = foo(A()) // error
diff --git a/tests/pos/i21410b.scala b/tests/pos/i21410b.scala
new file mode 100644
index 000000000000..a17ad59bc59e
--- /dev/null
+++ b/tests/pos/i21410b.scala
@@ -0,0 +1,10 @@
+object Test:
+  def foo[T](x: Option[T]): T = ???
+  def foo[T <: Tuple](x: T): Tuple.Map[T, List] = ???
+
+  val tup: (Int, String) = (1, "")
+
+  val x = foo(tup)
+  val y: (List[Int], List[String]) = x
+
+  val x2: (List[Int], List[String]) = foo(tup) // error