diff --git a/reflex/state.py b/reflex/state.py
index c16b37b69c..6af70db14f 100644
--- a/reflex/state.py
+++ b/reflex/state.py
@@ -30,6 +30,7 @@
     Type,
     Union,
     cast,
+    get_type_hints,
 )
 
 import dill
@@ -573,6 +574,15 @@ def __init_subclass__(cls, mixin: bool = False, **kwargs):
             for name, value in cls.__dict__.items()
             if types.is_backend_base_variable(name, cls)
         }
+        # Add annotated backend vars that do not have a default value.
+        new_backend_vars.update(
+            {
+                name: Var("", _var_type=annotation_value).get_default_value()
+                for name, annotation_value in get_type_hints(cls).items()
+                if name not in new_backend_vars
+                and types.is_backend_base_variable(name, cls)
+            }
+        )
 
         cls.backend_vars = {
             **cls.inherited_backend_vars,
diff --git a/tests/units/test_state.py b/tests/units/test_state.py
index 89aad15364..205162b9f2 100644
--- a/tests/units/test_state.py
+++ b/tests/units/test_state.py
@@ -3216,6 +3216,7 @@ class MixinState(State, mixin=True):
 
     num: int = 0
     _backend: int = 0
+    _backend_no_default: dict
 
     @rx.var(cache=True)
     def computed(self) -> str:
@@ -3243,11 +3244,16 @@ def test_mixin_state() -> None:
     """Test that a mixin state works correctly."""
     assert "num" in UsesMixinState.base_vars
     assert "num" in UsesMixinState.vars
-    assert UsesMixinState.backend_vars == {"_backend": 0}
+    assert UsesMixinState.backend_vars == {"_backend": 0, "_backend_no_default": {}}
 
     assert "computed" in UsesMixinState.computed_vars
     assert "computed" in UsesMixinState.vars
 
+    assert (
+        UsesMixinState(_reflex_internal_init=True)._backend_no_default  # type: ignore
+        is not UsesMixinState.backend_vars["_backend_no_default"]
+    )
+
 
 def test_child_mixin_state() -> None:
     """Test that mixin vars are only applied to the highest state in the hierarchy."""