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combination
sequential
and substitutes
operators on drug collections
#117
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My understanding is
An example of substitutes could be in civic:AID5 (attempt at a Curie notation there). It talks about the approval for the first generation TKIs erlotinib and gefitinib. They can be used interchangeably, one or the other in EGFR mutation NSCLC |
The documentation should be updated once there is consensus and other more detailed questions from @ahwagner are resolved |
@arpaddanos your definitions mirror my understanding. Beyond this, though, is the need for formal definitions and guidance on when the use of each. The motivation for this comes from the modeling I am doing for MetaKB, where I have created three distinct
NOTE: I use Therapeutic here instead of Drug as the term encompasses concepts such as Radiation Therapy; but the principle of these classes is meant to reflect the "drugs + interaction type" concept from CIViC. One of the challenges I have with this structure is the notion of |
Another question is about the use of |
@ahwagner I can't speak to the importance of capturing that information, but in terms of goals or data model I can say we are not currently capturing the sequence order, merely the collection, and I don't know that we've ever really discussed doing so. Also, longer term, I believe we are also intending to switch from Drug -> Therapy so our terminology will be in alignment there. |
Agreed with @acoffman above for sequential being stored in an unordered list and change of drug term coming. Also, with @arpaddanos about the basic definitions of these 3 drug interaction types. A few things:
|
The CIViC documentation lacks clear definitions of what the drug interaction types (
combination
,sequential
, andsubstitutes
) mean and when it is appropriate to use one over another.Starting the discussion here.
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