diff --git a/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/QualByDepth.java b/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/QualByDepth.java
index 8646a63e21d..ab9d8fc6b71 100644
--- a/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/QualByDepth.java
+++ b/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/QualByDepth.java
@@ -7,6 +7,7 @@
 import htsjdk.variant.variantcontext.VariantContext;
 import org.broadinstitute.barclay.help.DocumentedFeature;
 import org.broadinstitute.hellbender.engine.ReferenceContext;
+import org.broadinstitute.hellbender.exceptions.GATKException;
 import org.broadinstitute.hellbender.utils.MathUtils;
 import org.broadinstitute.hellbender.utils.Utils;
 import org.broadinstitute.hellbender.utils.genotyper.AlleleLikelihoods;
@@ -57,7 +58,7 @@ public Map<String, Object> annotate(final ReferenceContext ref,
                                         final VariantContext vc,
                                         final AlleleLikelihoods<GATKRead, Allele> likelihoods) {
         Utils.nonNull(vc);
-        if ( !vc.hasLog10PError() ) {
+        if ( !(vc.hasLog10PError() || vc.hasAttribute(GATKVCFConstants.RAW_QUAL_APPROX_KEY)) ) {
             return Collections.emptyMap();
         }
 
@@ -72,7 +73,16 @@ public Map<String, Object> annotate(final ReferenceContext ref,
             return Collections.emptyMap();
         }
 
-        final double qual = -10.0 * vc.getLog10PError();
+        final double qual;
+        if (vc.hasLog10PError()) {
+            qual = -10.0 * vc.getLog10PError();
+        } else {
+            try {
+                qual = vc.getAttributeAsInt(GATKVCFConstants.RAW_QUAL_APPROX_KEY, 0);
+            } catch (NumberFormatException e) {
+                throw new GATKException("Error at: " + vc.getContig() + ":" + vc.getStart() + " when parsing " + GATKVCFConstants.RAW_QUAL_APPROX_KEY + ": " + e.getMessage());
+            }
+        }
         double QD = qual / depth;
 
         // Hack: see note in the fixTooHighQD method below
diff --git a/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/allelespecific/AS_QualByDepth.java b/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/allelespecific/AS_QualByDepth.java
index f8bb3b3cea9..d0e15fa5ac0 100644
--- a/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/allelespecific/AS_QualByDepth.java
+++ b/src/main/java/org/broadinstitute/hellbender/tools/walkers/annotator/allelespecific/AS_QualByDepth.java
@@ -5,8 +5,6 @@
 import htsjdk.variant.variantcontext.GenotypesContext;
 import htsjdk.variant.variantcontext.VariantContext;
 import htsjdk.variant.vcf.VCFCompoundHeaderLine;
-import htsjdk.variant.vcf.VCFHeaderLine;
-import htsjdk.variant.vcf.VCFInfoHeaderLine;
 import org.apache.commons.lang3.StringUtils;
 import org.broadinstitute.barclay.help.DocumentedFeature;
 import org.broadinstitute.hellbender.engine.ReferenceContext;
@@ -78,7 +76,9 @@ public List<VCFCompoundHeaderLine> getRawDescriptions() {
     public Map<String, Object> annotate(final ReferenceContext ref,
                                         final VariantContext vc,
                                         final AlleleLikelihoods<GATKRead, Allele> likelihoods ) {
-        return Collections.emptyMap();
+        // first vc is used for the annotation and the second vc here is used just to get the alleles, so in this case we can pass the same vc for both
+        Map<String, Object> annotation = finalizeRawData(vc, vc);
+        return (annotation == null ? Collections.emptyMap() : Collections.singletonMap(getKeyNames().get(0), annotation.get(getKeyNames().get(0))));
     }
 
     /**
diff --git a/src/test/java/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotatorIntegrationTest.java b/src/test/java/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotatorIntegrationTest.java
index 6f3a87c60e7..7a5268a7d90 100644
--- a/src/test/java/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotatorIntegrationTest.java
+++ b/src/test/java/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotatorIntegrationTest.java
@@ -29,10 +29,7 @@
 
 import java.io.File;
 import java.io.IOException;
-import java.util.ArrayList;
-import java.util.List;
-import java.util.Map;
-import java.util.Set;
+import java.util.*;
 import java.util.stream.Collectors;
 import java.util.stream.Stream;
 
@@ -364,6 +361,46 @@ public void testDeNovo() {
         Assert.assertEquals(lociWithHighConfidenceDeNovo, new int[] {10130767, 10197999});
     }
 
+    //GVS vcfs have QUALapprox, but no QUAL. This tests that we can still calculate QD and AS_QD without QUAL (using QUALapprox and AS_QUALapprox)
+    @Test
+    public void addQdToGvsVcf() {
+        final File inputVCF = getTestFile("gvsCallsetWithNoQual.vcf");
+        final File outputVCF = createTempFile("output", ".vcf");
+        final ArgumentsBuilder args = new ArgumentsBuilder()
+                .addVCF(inputVCF)
+                .addOutput(outputVCF)
+                .addInterval("chr1:66506-66507")
+                .add("A", "QualByDepth")
+                .add("A", "AS_QualByDepth");
+        runCommandLine(args.getArgsList());
+
+        Map<Integer, Map<String, String>> expectedAnnotations = new HashMap<>();
+        Map<String, String> expectedAnnotations66506 = new HashMap<>();
+        Map<String, String> expectedAnnotations66507 = new HashMap<>();
+
+        // bi-allelic site
+        expectedAnnotations66506.put("QD", "4.23");
+        expectedAnnotations66506.put("AS_QD", "4.23");
+        //make sure that the AS_QUALapprox doesn't change from the input
+        expectedAnnotations66506.put("AS_QUALapprox", "0|110");
+
+        //multi-allelic site
+        expectedAnnotations66507.put("QD", "6.29");
+        expectedAnnotations66507.put("AS_QD", "[9.00, 9.26]");
+        expectedAnnotations66507.put("AS_QUALapprox", "0|396|537");
+
+        expectedAnnotations.put(66506, expectedAnnotations66506);
+        expectedAnnotations.put(66507, expectedAnnotations66507);
+
+
+        final List<VariantContext> outputVCs = VariantContextTestUtils.getVariantContexts(outputVCF);
+        for (final VariantContext outputVC : outputVCs) {
+            Assert.assertEquals(outputVC.getAttribute("QD"), expectedAnnotations.get(outputVC.getStart()).get("QD"));
+            Assert.assertEquals(outputVC.getAttribute("AS_QD").toString(), expectedAnnotations.get(outputVC.getStart()).get("AS_QD"));
+            Assert.assertEquals(outputVC.getAttribute("AS_QUALapprox"), expectedAnnotations.get(outputVC.getStart()).get("AS_QUALapprox"));
+        }
+    }
+
     private static String keyForVariant( final VariantContext variant ) {
         return String.format("%s:%d-%d %s", variant.getContig(), variant.getStart(), variant.getEnd(), variant.getAlleles());
     }
diff --git a/src/test/resources/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotator/gvsCallsetWithNoQual.vcf b/src/test/resources/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotator/gvsCallsetWithNoQual.vcf
new file mode 100644
index 00000000000..f9f63bcff26
--- /dev/null
+++ b/src/test/resources/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotator/gvsCallsetWithNoQual.vcf
@@ -0,0 +1,3394 @@
+##fileformat=VCFv4.2
+##FILTER=<ID=EXCESS_ALLELES,Description="Site has an excess of alternate alleles based on the input threshold">
+##FILTER=<ID=ExcessHet,Description="Site has excess het value larger than the threshold">
+##FILTER=<ID=LowQual,Description="Low quality">
+##FILTER=<ID=NO_HQ_GENOTYPES,Description="Site has no high quality variant genotypes">
+##FORMAT=<ID=AD,Number=R,Type=Integer,Description="Allelic depths for the ref and alt alleles in the order listed">
+##FORMAT=<ID=FT,Number=.,Type=String,Description="Genotype-level filter">
+##FORMAT=<ID=GQ,Number=1,Type=Integer,Description="Genotype Quality">
+##FORMAT=<ID=GT,Number=1,Type=String,Description="Genotype">
+##FORMAT=<ID=PGT,Number=1,Type=String,Description="Physical phasing haplotype information, describing how the alternate alleles are phased in relation to one another; will always be heterozygous and is not intended to describe called alleles">
+##FORMAT=<ID=PID,Number=1,Type=String,Description="Physical phasing ID information, where each unique ID within a given sample (but not across samples) connects records within a phasing group">
+##FORMAT=<ID=PS,Number=1,Type=Integer,Description="Phasing set (typically the position of the first variant in the set)">
+##FORMAT=<ID=RGQ,Number=1,Type=Integer,Description="Unconditional reference genotype confidence, encoded as a phred quality -10*log10 p(genotype call is wrong)">
+##GATKCommandLine=<ID=SelectVariants,CommandLine="SelectVariants --output /Users/mshand/Github/gatk/src/test/resources/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotator/gvcfOutput.vcf --variant gs://fc-eada2674-7c2b-42a6-8db3-0246872596dc/submissions/95259e2b-c797-43a8-97f4-cabdc24dce95/GvsQuickstartIntegration/737687d6-ccb2-4080-8942-bda67804deb3/call-QuickstartBeta/GvsJointVariantCalling/757b632b-68ee-4221-8b20-8d426fc85b07/call-GvsExtractCallset/GvsExtractCallset/0d064675-5959-4cdf-8c72-3a39f0f234ac/call-ExtractTask/shard-0/0000000000-quickit.vcf.gz --intervals chr1:66506-66507 --apply-jexl-filters-first false --invertSelect false --exclude-non-variants false --exclude-filtered false --preserve-alleles false --remove-unused-alternates false --restrict-alleles-to ALL --keep-original-ac false --keep-original-dp false --mendelian-violation false --invert-mendelian-violation false --mendelian-violation-qual-threshold 0.0 --select-random-fraction 1.0 --remove-fraction-genotypes 0.0 --ignore-non-ref-in-types false --fully-decode false --max-indel-size 2147483647 --min-indel-size 0 --max-filtered-genotypes 2147483647 --min-filtered-genotypes 0 --max-fraction-filtered-genotypes 1.0 --min-fraction-filtered-genotypes 0.0 --max-nocall-number 2147483647 --max-nocall-fraction 1.0 --set-filtered-gt-to-nocall false --allow-nonoverlapping-command-line-samples false --suppress-reference-path false --fail-on-unsorted-genotype false --genomicsdb-max-alternate-alleles 50 --call-genotypes false --genomicsdb-use-bcf-codec false --genomicsdb-shared-posixfs-optimizations false --genomicsdb-use-gcs-hdfs-connector false --interval-set-rule UNION --interval-padding 0 --interval-exclusion-padding 0 --interval-merging-rule ALL --read-validation-stringency SILENT --seconds-between-progress-updates 10.0 --disable-sequence-dictionary-validation false --create-output-bam-index true --create-output-bam-md5 false --create-output-variant-index true --create-output-variant-md5 false --max-variants-per-shard 0 --lenient false --add-output-sam-program-record true --add-output-vcf-command-line true --cloud-prefetch-buffer 40 --cloud-index-prefetch-buffer -1 --disable-bam-index-caching false --sites-only-vcf-output false --help false --version false --showHidden false --verbosity INFO --QUIET false --use-jdk-deflater false --use-jdk-inflater false --gcs-max-retries 20 --gcs-project-for-requester-pays  --disable-tool-default-read-filters false",Version="4.6.0.0-15-g9f267ba-SNAPSHOT",Date="September 11, 2024 at 10:58:07 AM EDT">
+##INFO=<ID=AC,Number=A,Type=Integer,Description="Allele count in genotypes, for each ALT allele, in the same order as listed">
+##INFO=<ID=AF,Number=A,Type=Float,Description="Allele Frequency, for each ALT allele, in the same order as listed">
+##INFO=<ID=AN,Number=1,Type=Integer,Description="Total number of alleles in called genotypes">
+##INFO=<ID=AS_QUALapprox,Number=1,Type=String,Description="Allele-specific QUAL approximations">
+##INFO=<ID=CALIBRATION_SENSITIVITY,Number=A,Type=String,Description="Calibration sensitivity corresponding to the value of SCORE">
+##INFO=<ID=DP,Number=1,Type=Integer,Description="Approximate read depth; some reads may have been filtered">
+##INFO=<ID=QUALapprox,Number=1,Type=Integer,Description="Sum of PL[0] values; used to approximate the QUAL score">
+##INFO=<ID=SCORE,Number=A,Type=String,Description="Score according to the model applied by ScoreVariantAnnotations">
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+##high_CALIBRATION_SENSITIVITY_INDEL=Sample Genotype FT filter value indicating that the genotyped allele failed INDEL model calibration sensitivity cutoff (0.99)
+##high_CALIBRATION_SENSITIVITY_SNP=Sample Genotype FT filter value indicating that the genotyped allele failed SNP model calibration sensitivity cutoff (0.997)
+##source=SelectVariants
+#CHROM	POS	ID	REF	ALT	QUAL	FILTER	INFO	FORMAT	ERS4367795	ERS4367796	ERS4367797
+chr1	66506	.	T	TAA	.	NO_HQ_GENOTYPES	AC=1;AF=0.167;AN=6;AS_QUALapprox=0|110;CALIBRATION_SENSITIVITY=.;QUALapprox=110;SCORE=.	GT:AD:GQ:RGQ	0/1:21,5:99:110	0/0:.:40	0/0:.:40
+chr1	66507	.	T	TATAATATATATTATATATTTATAGAATATAATATATATTTTATA,A	.	.	AC=1,2;AF=0.167,0.333;AN=6;AS_QUALapprox=0|396|537;CALIBRATION_SENSITIVITY=0.9884,0.5557;QUALapprox=396;SCORE=-0.6019,-0.4314	GT:AD:GQ:RGQ	0/1:18,5,0:99:396	0/2:9,0,5:99:132	0/2:12,0,14:99:405
diff --git a/src/test/resources/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotator/gvsCallsetWithNoQual.vcf.idx b/src/test/resources/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotator/gvsCallsetWithNoQual.vcf.idx
new file mode 100644
index 00000000000..861cbce9982
Binary files /dev/null and b/src/test/resources/org/broadinstitute/hellbender/tools/walkers/annotator/VariantAnnotator/gvsCallsetWithNoQual.vcf.idx differ